TXNRD2, thioredoxin reductase 2, 10587

N. diseases: 134; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017612
Disease: Glaucoma, Open-Angle
Glaucoma, Open-Angle 		0.400 GeneticVariation disease GWASDB Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. 22922875 2012
CUI: C4054695
Disease: Familial glucocorticoid deficiency
Familial glucocorticoid deficiency 		0.320 Biomarker disease GENOMICS_ENGLAND Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). 24601690 2014
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. 20571744 2010
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD The expression of thioredoxin-1/thioredoxin-2 and thioredoxin reductase-1/thioredoxin reductase-2 was significantly decreased in rats with ischemia/reperfusion injury, while it was increased by tetramethyl pyrazine administration. 19128823 2009
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.310 Biomarker phenotype PSYGENET Six SNPs from the first of three COMT/TXNRD2 haploblocks interacted with depressive symptoms on TMD pain (smallest p-value: 2.7 × 10(-10) ). 22337325 2012
CUI: C0340427
Disease: Familial dilated cardiomyopathy
Familial dilated cardiomyopathy 		0.300 GermlineCausalMutation disease ORPHANET Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy. 21247928 2011
CUI: C4049650
Disease: Familial Glucocorticoid Deficiency Type 1
Familial Glucocorticoid Deficiency Type 1 		0.300 GermlineCausalMutation disease ORPHANET Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). 24601690 2014
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.120 Biomarker group HPO
CUI: C0003123
Disease: Anorexia
Anorexia 		0.100 Biomarker disease HPO
CUI: C0004509
Disease: Azoospermia
Azoospermia 		0.100 Biomarker disease HPO
CUI: C0007194
Disease: Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 		0.100 Biomarker disease HPO
CUI: C0009806
Disease: Constipation
Constipation 		0.100 Biomarker phenotype HPO
CUI: C0010308
Disease: Congenital Hypothyroidism
Congenital Hypothyroidism 		0.100 Biomarker disease HPO
CUI: C0010417
Disease: Cryptorchidism
Cryptorchidism 		0.100 Biomarker disease HPO
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.100 Biomarker phenotype HPO
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive 		0.100 Biomarker disease HPO
CUI: C0018784
Disease: Sensorineural Hearing Loss (disorder)
Sensorineural Hearing Loss (disorder) 		0.100 Biomarker disease HPO
CUI: C0020461
Disease: Hyperkalemia
Hyperkalemia 		0.100 Biomarker phenotype HPO
CUI: C0020617
Disease: Hypoglycemic coma
Hypoglycemic coma 		0.100 Biomarker disease HPO
CUI: C0020625
Disease: Hyponatremia
Hyponatremia 		0.100 Biomarker phenotype HPO
CUI: C0020649
Disease: Hypotension
Hypotension 		0.100 Biomarker phenotype HPO
CUI: C0023787
Disease: Lipodystrophy
Lipodystrophy 		0.100 Biomarker disease HPO
CUI: C0026848
Disease: Myopathy
Myopathy 		0.100 Biomarker group HPO
CUI: C0034013
Disease: Precocious Puberty
Precocious Puberty 		0.100 Biomarker disease HPO
CUI: C0034372
Disease: Quadriplegia
Quadriplegia 		0.100 Biomarker disease HPO